Thioredoxin (TXN) Antibody

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity. ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).

Target	Thioredoxin (TXN)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/25. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 66-94 amino acids from the C-terminal region of human TXN.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P10599 (UniProt, ExPASy)
UniProt Secondary AC	B1ALW1, O60744, Q53X69, Q96KI3, Q9UDG5
UniProt Entry Name	THIO_HUMAN
NCBI Accession	NP_001231867.1 NP_003320.2
KEGG	hsa:7295
String	9606.ENSP00000363641
Molecular Weight	Calculated MW: 11.7 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Rat, Cow, Pig and Rabbit TXN.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Thioredoxin (TXN)

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