Tyrosine-Protein Kinase Receptor TYRO3 (TYRO3) Antibody

TYRO3: Tyrosine-protein kinase, also known as BYK, Brt, Dtk, Sky.Entrez Protein: NP_006284.It belongs to the Tyr protein kinase family (AXL/UFO subfamily).The UFO family of receptor tyrosine kinases is comprised of subfamily members Rse (also referred to as Tyro3 or Sky) and UFO (also called Tyro7 or Axl).Two distinct isoforms of Rse, designated Brt and Etk-2, have been described.Brt differs from Rse at its C-terminus, but more importantly lacks the N-terminal 31 amino acid signal peptide sequence present in Rse, which is replaced by a 27 amino acid Brt-specific sequence.It has been suggested that as a result of this alternative splicing event, Brt resides in the cytoplasm, unlike Rse which is expressed on the cell surface.Ekt-2 also lacks an N-terminal signal peptide which is substituted with a 45 amino acid Ekt-2-specific sequence.Protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation.

Target	Tyrosine-Protein Kinase Receptor TYRO3 (TYRO3)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA
Host	Mouse
Recommended dilutions	ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant extracellular fragment of human TYRO3 fused with hIgGFc tag expressed in HEK293 cell line.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q06418 (UniProt, ExPASy)
UniProt Secondary AC	O14953, Q86VR3
UniProt Entry Name	TYRO3_HUMAN
Gene Symbol	TYRO3
GeneID	7301
OMIM	600341
HGNC	12446
KEGG	hsa:7301
Ensembl	ENSG00000092445
String	9606.ENSP00000263798
Molecular Weight	96.9 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Tyrosine-Protein Kinase Receptor TYRO3 (TYRO3)

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