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TYRO Protein Tyrosine Kinase Binding Protein (TYROBP) Antibody
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Catalogue No: abx034547
Price:
US$326.25
(Size: 80 µl)
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TYROBP encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL.
Research Articles on TYRO Protein Tyrosine Kinase Binding Protein (TYROBP)
| Target | TYRO Protein Tyrosine Kinase Binding Protein (TYROBP) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 85-113 amino acids from the C-terminal region of human TYROBP. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O43914 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K2X0, F5H389, Q6FGA5, Q9UMT3 |
| UniProt Entry Name | TYOBP_HUMAN |
| Gene Symbol | TYROBP |
| KEGG | hsa:7305 |
| String | 9606.ENSP00000262629 |
| Molecular Weight | Calculated MW: 12.2 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Cow TYROBP. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |