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TYRO Protein Tyrosine Kinase Binding Protein (TYROBP) Antibody
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Catalogue No: abx004123
Price:
US$203.00
(Size: 20 µl)
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TYROBP Antibody is a Rabbit Polyclonal antibody against TYROBP. This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene.
Research Articles on TYRO Protein Tyrosine Kinase Binding Protein (TYROBP)
| Target | TYRO Protein Tyrosine Kinase Binding Protein (TYROBP) |
| Clonality | Polyclonal |
| Reactivity | Mouse, Rat |
| Tested Applications | ELISA |
| Host | Rabbit |
| Recommended dilutions | Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-113 of human TYROBP. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O43914 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K2X0, F5H389, Q6FGA5, Q9UMT3 |
| UniProt Entry Name | TYOBP_HUMAN |
| Gene Symbol | TYROBP |
| GeneID | 7305 |
| NCBI Accession | NP_003323.1 |
| KEGG | hsa:7305 |
| String | 9606.ENSP00000262629 |
| Molecular Weight | Calculated MW: 12 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |