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Tyrosine-Protein Kinase ITK/TSK (ITK) Antibody
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Catalogue No: abx240182
Price:
US$406.00
(Size: 100 µg)
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Tyrosine-Protein Kinase ITK/TSK (ITK) Antibody is a Rabbit Polyclonal antibody for the detection of ITK. Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation.
Research Articles on Tyrosine-Protein Kinase ITK/TSK (ITK)
| Target | Tyrosine-Protein Kinase ITK/TSK (ITK) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/200 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | IL2-inducible T-cell kinase |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | Q08881 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R752, Q32ML7 |
| UniProt Entry Name | ITK_HUMAN |
| Gene Symbol | ITK |
| GeneID | 3702 |
| OMIM | 186973 |
| HGNC | 6171 |
| KEGG | hsa:3702 |
| Ensembl | ENSG00000113263 |
| String | 9606.ENSP00000398655 |
| Molecular Weight | Observed MW: 68-72 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | This product is for research use only. |