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Polyubiquitin-B (UBB) Antibody
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Catalogue No: abx001741
Price:
US$203.00
(Size: 20 µl)
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UBB Antibody is a Rabbit Polyclonal antibody against UBB. This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. An aberrant form of this protein has been detected in patients with Alzheimer's disease and Down syndrome. Pseudogenes of this gene are located on chromosomes 1, 2, 13, and 17. Alternative splicing results in multiple transcript variants.
Research Articles on Polyubiquitin-B (UBB)
| Target | Polyubiquitin-B (UBB) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-228 of human Ubiquitin. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P0CG47 (UniProt, ExPASy) |
| Gene Symbol | UBB |
| GeneID | 7314 |
| OMIM | 191339 |
| NCBI Accession | BAC56955.1 |
| HGNC | 12463 |
| KEGG | hsa:7314 |
| Ensembl | ENSG00000170315 |
| String | 9606.ENSP00000304697 |
| Molecular Weight | Calculated MW: 26 kDa Observed MW: 17-110 kDa |
| Buffer | PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |