Ubiquitin-Conjugating Enzyme E2 D1 (UBE2D1) Antibody

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2D1 is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases.

Target	Ubiquitin-Conjugating Enzyme E2 D1 (UBE2D1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 111-140 amino acids from the C-terminal region of human UBE2D1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P51668 (UniProt, ExPASy)
UniProt Secondary AC	A6NLF6, A8K786
UniProt Entry Name	UB2D1_HUMAN
KEGG	hsa:7321
String	9606.ENSP00000363019
Molecular Weight	Calculated MW: 16.6 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Rat and Cow UBE2D1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Ubiquitin-Conjugating Enzyme E2 D1 (UBE2D1)

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