Ubiquitin-Like Protein ATG12 (ATG12) Antibody

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Catalogue No: abx148392
Price: US$406.00
(Size: 100 µg)
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IHC-P analysis of human kidney tissue, using ATG12 antibody (1/50 dilution).
Ubiquitin-Like Protein ATG12 (ATG12) Antibody

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Ubiquitin-Like Protein ATG12 (ATG12) Antibody is a Rabbit Polyclonal antibody for the detection of ATG12.

Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus.

Target Ubiquitin-Like Protein ATG12 (ATG12)
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications ELISA, IHC
Host Rabbit
Recommended dilutions IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen ATG12 autophagy related 12 homolog(S. cerevisiae)
Isotype IgG
Form Liquid
Purity ≥ 95% (SDS-PAGE)
Purification Purified by immunogen affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity 12 months.
UniProt Primary AC O94817 (UniProt, ExPASy)
UniProt Secondary AC Q6PJV2
UniProt Entry Name ATG12_HUMAN
Gene Symbol ATG12
GeneID 9140
OMIM 609608
HGNC 588
KEGG hsa:9140
Ensembl ENSG00000145782
String 9606.ENSP00000425107
Molecular Weight Observed MW: 48-50 kDa
Buffer PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration 2 mg/ml
Availability Shipped within 5-12 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on Ubiquitin-Like Protein ATG12 (ATG12)
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