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Ubiquitin Carboxyl-Terminal Hydrolase 10 (USP10) Antibody
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Catalogue No: abx219268
Price:
US$406.00
(Size: 100 µg)
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Ubiquitin Carboxyl-Terminal Hydrolase 10 (USP10) Antibody is a Rabbit Polyclonal antibody for the detection of USP10. Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989).
Research Articles on Ubiquitin Carboxyl-Terminal Hydrolase 10 (USP10)
| Target | Ubiquitin Carboxyl-Terminal Hydrolase 10 (USP10) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | IHC: 1/50 - 1/200, IF/ICC: 1/20 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | ubiquitin specific peptidase 10 |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | Q14694 (UniProt, ExPASy) |
| UniProt Secondary AC | B2RDJ8, B4DS84, Q9BWG7, Q9NSL7 |
| UniProt Entry Name | UBP10_HUMAN |
| Gene Symbol | USP10 |
| GeneID | 9100 |
| OMIM | 609818 |
| HGNC | 12608 |
| KEGG | hsa:9100 |
| Ensembl | ENSG00000103194 |
| String | 9606.ENSP00000457411 |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | This product is for research use only. |