E3 Ubiquitin-Protein Ligase UBR1 (UBR1) Antibody

The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome.

Target	E3 Ubiquitin-Protein Ligase UBR1 (UBR1)
Clonality	Polyclonal
Reactivity	Mouse
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 245-274 amino acids from the N-terminal region of human UBR1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q8IWV7 (UniProt, ExPASy)
UniProt Secondary AC	O60708, O75492, Q14D45, Q68DN9, Q8IWY6, Q96JY4
UniProt Entry Name	UBR1_HUMAN
Gene Symbol	UBR1
KEGG	hsa:197131
String	9606.ENSP00000290650
Molecular Weight	Calculated MW: 200 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on E3 Ubiquitin-Protein Ligase UBR1 (UBR1)

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