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Mitochondrial Uncoupling Protein 3 (UCP3) Antibody
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Catalogue No: abx001290
Price:
US$348.00
(Size: 60 µl)
Orders to United States ship from United States
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UCP3 Antibody is a Rabbit Polyclonal antibody against UCP3. The uncoupling protein UCP1 (formerly designated UCP) is an integral membrane protein unique to brown adipose tissue mitochondria. UCP1 forms a dimer that acts as a proton channel, which can uncouple oxidative phosphorylation by dissipating the electrochemical potential across the inner mitochondrial membrane. This process induces heat production in brown adipose tissue and is involved in regulation of body temperature and glucose metabolism. UCP2 is a structurally related protein that also uncouples mitochondrial respiration. It is more widely expressed in human and mouse tissues, including white adipose tissue and muscle, than is UCP1. UCP2 is thought to play a role in body weight regulation. An additional UCP family member, UCP3, is highly muscle specific and is possibly involved in the uncoupling of oxidative phosphorylation in skeletal muscle.
Research Articles on Mitochondrial Uncoupling Protein 3 (UCP3)
| Target | Mitochondrial Uncoupling Protein 3 (UCP3) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human UCP3 |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P55916 (UniProt, ExPASy) |
| UniProt Secondary AC | O60475, Q96HL3 |
| UniProt Entry Name | UCP3_HUMAN |
| Gene Symbol | UCP3 |
| GeneID | 7352 |
| NCBI Accession | NP_073714.1 |
| KEGG | hsa:7352 |
| String | 9606.ENSP00000323740 |
| Molecular Weight | Calculated MW: 22 kDa/29 kDa/34 kDa Observed MW: 34 kDa |
| Buffer | PBS, pH 7.3, containing 0.01% thiomersal, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
