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UDP-Glucuronosyltransferase 1-1 (UGT1A1) Antibody
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Catalogue No: abx004726
Price:
US$203.00
(Size: 20 µl)
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UGT1A1 Antibody is a Rabbit Polyclonal antibody against UGT1A1. This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.
Research Articles on UDP-Glucuronosyltransferase 1-1 (UGT1A1)
| Target | UDP-Glucuronosyltransferase 1-1 (UGT1A1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000 - 1/5000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human UGT1A1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P22309 (UniProt, ExPASy) |
| UniProt Secondary AC | A6NJC3, B8K286 |
| UniProt Entry Name | UD11_HUMAN |
| Gene Symbol | UGT1A1 |
| GeneID | 54658 |
| NCBI Accession | NP_000454.1 |
| KEGG | hsa:54658 |
| String | 9606.ENSP00000304845 |
| Molecular Weight | Calculated MW: 60 kDa Observed MW: 60 kDa |
| Buffer | PBS, pH 7.3, containing 0.09% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |