Unc-51 Like Autophagy Activating Kinase 2 (ULK2) Antibody

Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). Two human homologs of the yeast autophagy-specific kinase exist: ULK1 (APG1) and ULK2. APG1 plays a critical role in regulating key elements of the autophagy pathway. APG1 stimulates autophagy, leading to autophagy-dependent restriction of cell growth and ultimately cell apoptosis at high levels of activity, and is a negative regulator of mTOR signaling.

Target	Unc-51 Like Autophagy Activating Kinase 2 (ULK2)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 235-264 amino acids from the N-terminal region of human ULK2.
Isotype	IgG
Form	Liquid
Purification	Purified Rabbit Polyclonal Antibody.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q8IYT8 (UniProt, ExPASy)
UniProt Secondary AC	A8MY69, O75119
UniProt Entry Name	ULK2_HUMAN
KEGG	hsa:9706
String	9606.ENSP00000378914
Molecular Weight	Calculated MW: 113 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse ULK2.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Unc-51 Like Autophagy Activating Kinase 2 (ULK2)

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