Protein Unc-13 Homolog B (UNC13B) Antibody

This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq].

Target	Protein Unc-13 Homolog B (UNC13B)
Clonality	Polyclonal
Reactivity	Mouse
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 263-292 amino acids from the N-terminal region of human UNC13B.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O14795 (UniProt, ExPASy)
UniProt Secondary AC	Q2NKJ5, Q5VYM8
UniProt Entry Name	UN13B_HUMAN
Gene Symbol	UNC13B
KEGG	hsa:10497
String	9606.ENSP00000367756
Molecular Weight	Calculated MW: 181 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Protein Unc-13 Homolog B (UNC13B)

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