Regulator of Nonsense Transcripts 1 (UPF1) Antibody

UPF1 Antibody is a Rabbit Polyclonal antibody against UPF1. Upf1 was identified as an active component in nonsense-mediated decay (NMD), an mRNA surveillance mechanism in eukaryotic cells that degrades mRNAs containing premature termination codonsUpf1 was found to be an ATP-dependent RNA helicase in the cytoplasm and was later shown to be a component of cytoplasmic P-bodiesUpf1 phosphorylation mediates the repression of translation that accompanies NMD, allowing mRNA accessibility to the NMD machineryTwo other active components of NMD, Upf2 and Upf3, were also identified and described as having perinuclear and nucleocytoplasmic localization, respectively.

Target	Regulator of Nonsense Transcripts 1 (UPF1)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide of human UPF1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q92900 (UniProt, ExPASy)
UniProt Secondary AC	O00239, O43343, Q86Z25, Q92842
UniProt Entry Name	RENT1_HUMAN
Gene Symbol	UPF1
GeneID	5976
KEGG	hsa:5976
String	9606.ENSP00000470142
Buffer	PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Regulator of Nonsense Transcripts 1 (UPF1)

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