Ubiquitin Carboxyl-Terminal Hydrolase 2 (USP2) Antibody

REQUEST MORE INFO
Catalogue No: abx031538
Price: US$326.25
(Size: 80 µl)

Click on the image to see the image legend

Available Options

* Size:


Add to Shopping Cart Buy It Now GET A QUOTE

Documents

Datasheet SDS
Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs), 1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.

Target Ubiquitin Carboxyl-Terminal Hydrolase 2 (USP2)
Clonality Polyclonal
Reactivity Human, Rat
Tested Applications ELISA, WB, IHC
Host Rabbit
Recommended dilutions WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen KLH-conjugated synthetic peptide between 71-101 amino acids from the N-terminal region of human USP2.
Isotype IgG
Form Liquid
Purification Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC O75604 (UniProt, ExPASy)
UniProt Secondary AC B0YJB8, E9PPM2, Q8IUM2, Q8IW04, Q96MB9, Q9BQ21
UniProt Entry Name UBP2_HUMAN
NCBI Accession NP_001230688.1 NP_004196.4 NP_741994.1
KEGG hsa:9099
String 9606.ENSP00000260187
Molecular Weight Calculated MW: 68.1 kDa
Buffer PBS containing 0.09% sodium azide.
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Ubiquitin Carboxyl-Terminal Hydrolase 2 (USP2)


Write a review