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Ubiquitin Carboxyl-Terminal Hydrolase 20 (USP20) Antibody
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Catalogue No: abx028091
Price:
US$290.00
(Size: 80 µl)
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Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'-and 'Lys-63'-linked polyubiquitin chains.
Research Articles on Ubiquitin Carboxyl-Terminal Hydrolase 20 (USP20)
| Target | Ubiquitin Carboxyl-Terminal Hydrolase 20 (USP20) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 310-339 amino acids from the Central region of human USP20. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9Y2K6 (UniProt, ExPASy) |
| UniProt Secondary AC | Q541F1, Q8IXQ1, Q96LG5, Q9UQN8, Q9UQP0 |
| UniProt Entry Name | UBP20_HUMAN |
| Gene Symbol | USP20 |
| String | 9606.ENSP00000313811 |
| Molecular Weight | Calculated MW: 102 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Cow USP20. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |