Ubiquitin Specific Peptidase 8 (USP8) Antibody

Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. This antibody is supplied as crude ascites.

Target	Ubiquitin Specific Peptidase 8 (USP8)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Mouse
Recommended dilutions	WB: 1/500 - 1/4000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 1-30 amino acids from the C-terminal region of human USP8.
Isotype	IgG1
Form	Liquid
Purification	Unpurified crude ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P40818 (UniProt, ExPASy)
UniProt Secondary AC	B4DKA8, Q2TB31, Q7Z3U2, Q86VA0, Q8IWI7
UniProt Entry Name	UBP8_HUMAN
KEGG	hsa:9101
String	9606.ENSP00000379721
Molecular Weight	Calculated MW: 128 kDa
Buffer	Ascites containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse USP8.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Ubiquitin Specific Peptidase 8 (USP8)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue