Vascular Endothelial Growth Factor A (VEGFA) Antibody

Vascular Endothelial Growth Factor A (VEGFA) Antibody is a Mouse Monoclonal antibody for the detection of VEGF.

VEGFA, also named as VEGF or VPF, belongs to the PDGF/VEGF growth factor family. It is a growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. VEGFA induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. It binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. Defects in VEGFA are a cause of susceptibility to microvascular complications of diabetes type 1 (MVCD1). VEGFA has 13 isoforms with MW 16kd to 45kd. Some isoforms has homodimer form, such as VEGFA189 (38kd), VEFGA110 (34kd). VEGFA is a 34kd to 42kd, dimeric, disulfide-bound glycoprotein. VEGF-A exists in at least seven homodimeric isoforms. The monomers consist of 121, 145, 148, 165, 183, 189, or 206 amino acids (PMID:15602010). This antibody can recognize all the isoforms of VEFGA.

Target	Vascular Endothelial Growth Factor A (VEGFA)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Mouse
Recommended dilutions	WB: 1/1000 - 1/4000, IHC: 1/50 - 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	vascular endothelial growth factor A
Isotype	IgG2b
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by Protein A and Protein G affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	P15692 (UniProt, ExPASy)
GeneID	7422
OMIM	192240
Molecular Weight	Observed MW: 45 kDa
Buffer	0.01 M PBS, pH 7.4.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on Vascular Endothelial Growth Factor A (VEGFA)

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