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Target | Vascular Endothelial Growth Factor receptor-2 Fc Chimera (VEGFR2 Fc) |
Origin | Human |
Expression | Recombinant |
Tested Applications | SDS-PAGE |
Host | Insect |
Recommended dilutions | Optimal dilutions/concentrations should be determined by the end user. |
Form | Lyophilized |
Purity | > 90% (SDS-PAGE) |
Purification | Purified by proprietary chromatographic techniques. |
Reconstitution | Reconstitute in sterile water to a concentration of at least 50 µg/ml. This stock solution can be further diluted if required. |
Storage | Store dessicated at -20 °C for long-term storage. Upon reconstitution, store at 4 °C for up to 7 days and store below -18 °C for long-term storage. For long-term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles. |
Validity | Stable at room temperature for up to 3 weeks. |
UniProt Primary AC | P35968 (UniProt, ExPASy) |
UniProt Secondary AC | A2RRS0, B5A925, C5IFA0, O60723, Q14178 |
UniProt Entry Name | VGFR2_HUMAN |
KEGG | hsa:3791 |
String | 9606.ENSP00000263923 |
Enzyme Commission Number | EC:2.7.10.1 |
Molecular Weight | 145 kDa |
Sequence Fragment | 968 AA. The soluble receptor protein contains only the first 7 extracellular domains, which is sufficient for ligand binding. |
Sequence | ASVGLPSVSL DLPRLSIQKD ILTIKANTTL QITCRGQRDL DWLWPNNQSG SEQRVEVTEC SDGLFCKTLT IPKVIGNDTG AYKCFYRETD LASVIYVYVQ DYRSPFIASV SDQHGVVYIT ENKNKTVVIP CLGSISNLNV SLCARYPEKR FVPDGNRISW DSKKGFTIPS YMISYAGMVF CEAKINDESY QSIMYIVVVV GYRIYDVVLS PSHGIELSVG EKLVLNCTAR TELNVGIDFN WEYPSSKHQH KKLVNRDLKT QSGSEMKKFL STLTIDGVTR SDQGLYTCAA SSGLMTKKNS TFVRVHEKPF VAFGSGMESL VEATVGERVR IPAKYLGYPP PEIKWYKNGI PLESNHTIKA GHVLTIMEVS ERDTGNYTVI LTNPISKEKQ SHVVSLVVYV PPQIGEKSLI SPVDSYQYGT TQTLTCTVYA IPPPHHIHWY WQLEEECANE PSQAVSVTNP YPCEEWRSVE DFQGGNKIEV NKNQFALIEG KNKTVSTLVI QAANVSALYK CEAVNKVGRG ERVISFHVTR GPEITLQPDM QPTEQESVSL WCTADRSTFE NLTWYKLGPQ PLPIHVGELP TPVCKNLDTL WKLNATMFSN STNDILIMEL KNASLQDQGD YVCLAQDRKT KKRHCVVRQL TVLERVAPTI TGNLENQTTS IGESIEVSCT ASGNPPPQIM WFKDNETLVE DSGIVLKDGN RNLTIRRVRK EDEGLYTCQA CSVLGCAKVE AFFIIEGANA SDKTHTCPPC PAPELLGGPS VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKA KGQPREPQVY TLPPSREEMT KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPMLD SDGSFFLYSK LTVDKSRWQQ GNVFSCSVMH EALHNHYTQK SLSLSPGK |
Tag | Recombinant Human Soluble VEGFR2 is fused with the Fc domain of Human IgG1. |
Buffer | Prior to lyophilization: 1X PBS, pH 7.2. |
Biological Activity | Inhibits the VEGF-dependent proliferation of Human umbilical vein endothelial cells. |
Concentration | Prior to lyophilization: 1 mg/ml |
Availability | Shipped within 5-10 working days. |
Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |