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Proto-Oncogene Vav (VAV1) Antibody
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Catalogue No: abx011903
Price:
US$420.50
(Size: 100 µl)
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The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.
Research Articles on Proto-Oncogene Vav (VAV1)
| Target | Proto-Oncogene Vav (VAV1) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, FCM |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, WB: 1/250, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human VAV1 (AA: 121-324) expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Purified from ascites by Protein G chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P15498 (UniProt, ExPASy) |
| UniProt Secondary AC | B4DVK9, M0QXX6, Q15860 |
| UniProt Entry Name | VAV_HUMAN |
| Gene Symbol | VAV1 |
| GeneID | 7409 |
| OMIM | 164875 |
| HGNC | 12657 |
| KEGG | hsa:7409 |
| Ensembl | ENSG00000141968 |
| String | 9606.ENSP00000472929 |
| Molecular Weight | 98.3 kDa |
| Buffer | PBS, containing 0.05% sodium azide. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |