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Voltage-Dependent Anion-Selective Channel Protein 1 (VDAC1) Antibody
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Catalogue No: abx032902
Price:
US$326.25
(Size: 80 µl)
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VDAC1 forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. The protein may participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
Research Articles on Voltage-Dependent Anion-Selective Channel Protein 1 (VDAC1)
| Target | Voltage-Dependent Anion-Selective Channel Protein 1 (VDAC1) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 95-124 amino acids from the Central region of human VDAC1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P21796 (UniProt, ExPASy) |
| UniProt Secondary AC | B3KVK4, D3DQ93, Q5FVE7, Q9UIQ5, Q9UPL0 |
| UniProt Entry Name | VDAC1_HUMAN |
| KEGG | hsa:7416 |
| String | 9606.ENSP00000265333 |
| Molecular Weight | Calculated MW: 30.8 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse, Rat, Cow and Rabbit VDAC1. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |