Vitamin D3 Receptor (VDR) Antibody

This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding the same protein. This antibody is supplied as crude ascites.

Target	Vitamin D3 Receptor (VDR)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Mouse
Recommended dilutions	WB: 1/500 - 1/16000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified His-tagged Human VDR protein (Fragment)
Isotype	IgA
Form	Liquid
Purification	Unpurified crude ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P11473 (UniProt, ExPASy)
UniProt Secondary AC	B2R5Q1, G3V1V9, Q5PSV3
UniProt Entry Name	VDR_HUMAN
KEGG	hsa:7421
String	9606.ENSP00000447173
Molecular Weight	Calculated MW: 48.3 kDa
Buffer	Ascites containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Vitamin D3 Receptor (VDR)

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