Vitamin D3 Receptor (VDR) Antibody

VDR Antibody is a Rabbit Polyclonal antibody against VDR. The vitamin D receptor (VDR), also known as the calcitriol receptor, and also known as NR1I1 (nuclear receptor subfamily 1, group I, member 1), is a member of the nuclear receptor family of transcription factorsUpon activation by vitamin D, the VDR forms a heterodimer with the retinoid-X receptor and binds to hormone response elements on DNA resulting in expression or trans-repression of specific gene productsIt is an intracellular hormone receptor that specifically binds 1,25(OH)2D3 and mediates its effectsDownstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancerDefects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A)A disorder of vitamin D metabolism results in severe rickets, hypocalcemia and secondary hyperpaRathyroidismMost patients have total alopecia in addition to ricketsThis antibody is a rabbit polyclonal antibody to human VDR.

Target	Vitamin D3 Receptor (VDR)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P11473 (UniProt, ExPASy)
UniProt Secondary AC	B2R5Q1, G3V1V9, Q5PSV3
UniProt Entry Name	VDR_HUMAN
Gene Symbol	VDR
GeneID	7421
KEGG	hsa:7421
String	9606.ENSP00000447173
Buffer	PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Vitamin D3 Receptor (VDR)

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