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Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
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Catalogue No: abx032865
Price:
US$326.25
(Size: 80 µl)
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Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of VHL gene is the basis of familial inheritance of VHL syndrome. The protein is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein.
Research Articles on Von Hippel-Lindau Disease Tumor Suppressor (VHL)
| Target | Von Hippel-Lindau Disease Tumor Suppressor (VHL) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 181-210 amino acids from the C-terminal region of human VHL. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P40337 (UniProt, ExPASy) |
| UniProt Secondary AC | B2RE45, Q13599, Q6PDA9 |
| UniProt Entry Name | VHL_HUMAN |
| KEGG | hsa:7428 |
| String | 9606.ENSP00000256474 |
| Molecular Weight | Calculated MW: 24.2 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |