PYM Homolog 1 Exon Junction Complex-Associated Factor (WIBG) Antibody

Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC.

Target	PYM Homolog 1 Exon Junction Complex-Associated Factor (WIBG)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 12-40 amino acids from the N-terminal region of human WIBG.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9BRP8 (UniProt, ExPASy)
UniProt Secondary AC	B6ZDM5, Q8IXJ8, Q8N8E7
UniProt Entry Name	PYM1_HUMAN
Gene Symbol	PYM1
String	9606.ENSP00000386156
Molecular Weight	Calculated MW: 22.7 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse and Cow PYM1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on PYM Homolog 1 Exon Junction Complex-Associated Factor (WIBG)

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