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WNT1 Inducible Signaling Pathway Protein 1 / WISP1 (CCN4) Antibody
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Catalogue No: abx002388
Price:
US$203.00
(Size: 20 µl)
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WISP1 Antibody is a Rabbit Polyclonal antibody against WISP1. This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified.
Research Articles on WNT1 Inducible Signaling Pathway Protein 1 / WISP1 (CCN4)
| Target | WNT1 Inducible Signaling Pathway Protein 1 / WISP1 (CCN4) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 158-367 of human WISP1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O95388 (UniProt, ExPASy) |
| UniProt Secondary AC | A8KAG6, E7EMM5, Q5JBS6, Q5JBS7, Q5JBS8, Q9HCS3 |
| UniProt Entry Name | WISP1_HUMAN |
| Gene Symbol | WISP1 |
| GeneID | 8840 |
| NCBI Accession | NP_003873.1 |
| KEGG | hsa:8840 |
| String | 9606.ENSP00000250160 |
| Molecular Weight | Calculated MW: 40 kDa Observed MW: 45 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |