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WNT1 Inducible Signaling Pathway Protein 3 / WISP3 (CCN6) Antibody
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Catalogue No: abx032755
Price:
US$290.00
(Size: 80 µl)
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WISP3 is a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. WISP3 is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of the WISP3 gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis.
Research Articles on WNT1 Inducible Signaling Pathway Protein 3 / WISP3 (CCN6)
| Target | WNT1 Inducible Signaling Pathway Protein 3 / WISP3 (CCN6) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 305-335 amino acids from the Central region of human WISP3. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O95389 (UniProt, ExPASy) |
| UniProt Secondary AC | Q3KR29, Q5H8W4, Q6UXH6 |
| UniProt Entry Name | CCN6_HUMAN |
| KEGG | hsa:8838 |
| String | 9606.ENSP00000357655 |
| Molecular Weight | Calculated MW: 39.3 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |