Proto-oncogene Wnt-3 (WNT3) Antibody

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region.

Target	Proto-oncogene Wnt-3 (WNT3)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 155-184 amino acids from the Central region of human WNT3.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P56703 (UniProt, ExPASy)
UniProt Secondary AC	Q2M237, Q9H1J9
UniProt Entry Name	WNT3_HUMAN
KEGG	hsa:7473
String	9606.ENSP00000225512
Molecular Weight	Calculated MW: 39.6 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Chicken and Xenopus WNT3.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Proto-oncogene Wnt-3 (WNT3)

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