+44 (0) 1223 755950
+1 832 327 7413
Bifunctional 3'-5' Exonuclease/ATP-Dependent Helicase WRN (WRN) Antibody
REQUEST MORE INFO
Catalogue No: abx026592
Price:
US$290.00
(Size: 80 µl)
Reviews: 
(0 Publications and Reviews)
(0 Publications and Reviews)
Click on the image to see the image legend
This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.
Research Articles on Bifunctional 3'-5' Exonuclease/ATP-Dependent Helicase WRN (WRN)
| Target | Bifunctional 3'-5' Exonuclease/ATP-Dependent Helicase WRN (WRN) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 787-816 amino acids from the Central region of human WRN. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q14191 (UniProt, ExPASy) |
| UniProt Secondary AC | A1KYY9 |
| UniProt Entry Name | WRN_HUMAN |
| Gene Symbol | WRN |
| GeneID | 7486 |
| OMIM | 114500 |
| HGNC | 12791 |
| KEGG | hsa:7486 |
| Ensembl | ENSG00000165392 |
| String | 9606.ENSP00000298139 |
| Molecular Weight | Calculated MW: 162 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |