WW Domain Containing Transcription Regulator Protein 1 (WWTR1) Antibody

Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.

Target	WW Domain Containing Transcription Regulator Protein 1 (WWTR1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 370-398 amino acids from the C-terminal region of human WWTR1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9GZV5 (UniProt, ExPASy)
UniProt Secondary AC	D3DNH7, Q8N3P2, Q9Y3W6
UniProt Entry Name	WWTR1_HUMAN
Gene Symbol	WWTR1
String	9606.ENSP00000419465
Molecular Weight	Calculated MW: 44.1 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse WWTR1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on WW Domain Containing Transcription Regulator Protein 1 (WWTR1)

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