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X-Ray Repair Cross Complementing 6 (XRCC6) Antibody
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Catalogue No: abx000886
Price:
US$203.00
(Size: 20 µl)
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XRCC6 Antibody is a Rabbit Polyclonal antibody against XRCC6. X-ray repair cross-complementing protein 6 (XRCC6) gene encodes subunit p70 of the p70/p80 autoantigen which has a role in DNA repair or transposition. DNA helicase II complex binds preferentially to fork-like ends of double-standed DNA in a cell cycle-dependent manner, which may be mediated by XRCC6. XRCC6/5 can form a heterdimer, which function as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA, and also it can stablize broken DNA ends and bringing them together. Otherwise, XRCC5/6 heterdimer together with APEX1 can negatively regulate of transcription.
Research Articles on X-Ray Repair Cross Complementing 6 (XRCC6)
| Target | X-Ray Repair Cross Complementing 6 (XRCC6) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 408-609 of human Ku70. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P12956 (UniProt, ExPASy) |
| UniProt Secondary AC | B1AHC8, Q6FG89, Q9UCQ2, Q9UCQ3 |
| UniProt Entry Name | XRCC6_HUMAN |
| Gene Symbol | XRCC6 |
| GeneID | 2547 |
| NCBI Accession | NP_001460.1 |
| KEGG | hsa:2547 |
| String | 9606.ENSP00000352257 |
| Molecular Weight | Calculated MW: 70 kDa Observed MW: 70 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |