+44 (0) 1223 755950
+1 832 327 7413
Tyrosine-Protein Kinase ZAP-70 (ZAP70) Antibody
REQUEST MORE INFO
Catalogue No: abx016023
Price:
US$427.75
(Size: 100 µl)
Reviews: 
(0 Publications and Reviews)
(0 Publications and Reviews)
Click on the image to see the image legend
ZAP70 (zeta-chain associated protein kinase), a 70 kDa member of the SYK tyrosine kinase family, plays a central role in lymphocyte activation and development, and is implicated in several immune disorders.ZAP70 controls TCR (T-cell antigen receptor)-linked signal transduction pathways.Its key role in thymocytes development and mature T lymphocytes activation has been illustrated by the characterization of several human immunodeficiencies presenting with mutations in the ZAP70 gene.ZAP70 is also expressed in several types of B-cell neoplasm and is easily detected by immunohistochemistry, providing a useful prognostic marker in patients with chronic lymphocytic leukaemia.
Research Articles on Tyrosine-Protein Kinase ZAP-70 (ZAP70)
| Target | Tyrosine-Protein Kinase ZAP-70 (ZAP70) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human ZAP70 expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P43403 (UniProt, ExPASy) |
| UniProt Secondary AC | A6NFP4, Q6PIA4, Q8IXD6, Q9UBS6 |
| UniProt Entry Name | ZAP70_HUMAN |
| Gene Symbol | ZAP70 |
| GeneID | 7535 |
| OMIM | 176947 |
| HGNC | 12858 |
| KEGG | hsa:7535 |
| Ensembl | ENSG00000115085 |
| String | 9606.ENSP00000264972 |
| Molecular Weight | 70 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |