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Zona Pellucida Sperm-Binding Protein 3 (ZP3) Antibody
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Catalogue No: abx029377
Price:
US$326.25
(Size: 80 µl)
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The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo protein composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain protein hypothesized that furin cleavage results in release of the mature the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene.
Research Articles on Zona Pellucida Sperm-Binding Protein 3 (ZP3)
| Target | Zona Pellucida Sperm-Binding Protein 3 (ZP3) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 353-380 amino acids from the C-terminal region of human ZP3. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P21754 (UniProt, ExPASy) |
| UniProt Secondary AC | Q06633, Q29RW0 |
| UniProt Entry Name | ZP3_HUMAN |
| Gene Symbol | ZP3 |
| KEGG | hsa:7784 |
| String | 9606.ENSP00000378326 |
| Molecular Weight | Calculated MW: 47 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |