ALK Tyrosine Kinase Receptor (ALK) Antibody

ALK, a member of the insulin receptor subfamily of Tyr protein kinases, is an orphan receptor. It appears to play an important role in the normal development and function of the nervous system. This Type I membrane protein is expressed in brain and CNS and in the small intestine and testis, but not in normal lymphoid cells. A form of non-Hodgkin's lymphoma is characterized by a chromosomal translocation t (2;5) (p23;q35) that involves NPM1 and ALK. The protein contains 1 LDL-receptor class A domain and 2 putative MAM domains.

Target	ALK Tyrosine Kinase Receptor (ALK)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 636-666 amino acids from the Central region of human ALK.
Isotype	IgG
Form	Liquid
Purification	Purified Rabbit Polyclonal Antibody.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9UM73 (UniProt, ExPASy)
UniProt Secondary AC	Q4ZFX9, Q53QQ6, Q53RZ4, Q59FI3, Q9Y4K6
UniProt Entry Name	ALK_HUMAN
NCBI Accession	NP_004295.2
String	9606.ENSP00000373700
Molecular Weight	Calculated MW: 176 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on ALK Tyrosine Kinase Receptor (ALK)

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