Rho Guanine Nucleotide Exchange Factor 3 (ARHGEF3) Antibody

Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Target	Rho Guanine Nucleotide Exchange Factor 3 (ARHGEF3)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 211-240 amino acids from the Central region of human ARHGEF3.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9NR81 (UniProt, ExPASy)
UniProt Entry Name	ARHG3_HUMAN
Gene Symbol	ARHGEF3
String	9606.ENSP00000341071
Molecular Weight	Calculated MW: 59.8 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Chicken and Monkey ARHGEF3.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Rho Guanine Nucleotide Exchange Factor 3 (ARHGEF3)

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