Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) Antibody

The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1. A t (1;12) (q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Alternative splicing results in multiple transcript variants.

Target	Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IF/ICC: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 513-544 amino acids from the Central region of human ARNT.
Isotype	IgG
Form	Liquid
Purification	Purified Rabbit Polyclonal Antibody.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P27540 (UniProt, ExPASy)
UniProt Secondary AC	B2R9H1, C4AMA1, F8WAP6, Q59ED4, Q5QP39, Q8NDC7
UniProt Entry Name	ARNT_HUMAN
KEGG	hsa:405
String	9606.ENSP00000351407
Molecular Weight	Calculated MW: 86.6 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Cow ARNT.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT)

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