Barrier-To-Autointegration Factor (BANF1) Antibody

The protein encoded by this gene was first identified by its ability to protect retroviruses from intramolecular integration and therefore promote intermolecular integration into the host cell genome. The protein forms a homodimer which localizes to both the nucleus and cytoplasm and is specifically associated with chromosomes during mitosis. This protein binds to double stranded DNA in a non-specific manner and also binds to LEM-domain containing proteins of the nuclear envelope. This protein is thought to facilitate nuclear reassembly by binding with both DNA and inner nuclear membrane proteins and thereby recruit chromatin to the nuclear periphery. Alternative splicing results in multiple transcript variants encoding the same protein.

Target	Barrier-To-Autointegration Factor (BANF1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 37-65 amino acids from the Central region of human BANF1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O75531 (UniProt, ExPASy)
UniProt Secondary AC	O60558, Q6FGG7
UniProt Entry Name	BAF_HUMAN
Gene Symbol	BANF1
GeneID	8815
OMIM	603811
HGNC	17397
KEGG	hsa:8815
String	9606.ENSP00000310275
Molecular Weight	Calculated MW: 10.1 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Rat and Cow BANF1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Barrier-To-Autointegration Factor (BANF1)

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