Beta-Adrenergic Receptor Kinase 2 (GRK3) Antibody

The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the ADRBK2 enzyme, also known as GRK3, has 85% amino acid similarity with ADRBK1, with the protein kinase catalytic domain having 95% similarity. The ADRBK2 mRNA is approximately 8 kilobases with a distribution similar to that of ADRBK1. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function.

Target	Beta-Adrenergic Receptor Kinase 2 (GRK3)
Clonality	Polyclonal
Reactivity	Human, Mouse, Monkey
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 633-660 amino acids from the C-terminal region of human AD_K2.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P35626 (UniProt, ExPASy)
UniProt Secondary AC	Q9UGW9
UniProt Entry Name	ARBK2_HUMAN
NCBI Accession	NP_005151.2
KEGG	hsa:157
String	9606.ENSP00000317578
Molecular Weight	Calculated MW: 79.7 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Beta-Adrenergic Receptor Kinase 2 (GRK3)

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