Myc Box-Dependent-Interacting Protein 1 (BIN1) Antibody

This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynanim, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.

Target	Myc Box-Dependent-Interacting Protein 1 (BIN1)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 360-389 amino acids from the Central region of human BIN1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O00499 (UniProt, ExPASy)
UniProt Entry Name	BIN1_HUMAN
Gene Symbol	BIN1
KEGG	hsa:274
String	9606.ENSP00000316779
Molecular Weight	Calculated MW: 64.7 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Rat BIN1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Myc Box-Dependent-Interacting Protein 1 (BIN1)

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