Chitinase 1 (CHIT1) Antibody

CHIT1:chitinase 1 (chitotriosidase).Chitotriosidase is a 50 kDa secreted glycoprotein that belongs to glycohydrolase family # 18.It is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients.The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture.Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression.This enzyme may play a role in the degradation of chitin-containing pathogens.

Target	Chitinase 1 (CHIT1)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA
Host	Mouse
Recommended dilutions	ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of CHIT1 (aa22-137) expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q13231 (UniProt, ExPASy)
UniProt Entry Name	CHIT1_HUMAN
Gene Symbol	CHIT1
GeneID	1118
OMIM	600031
HGNC	1936
KEGG	hsa:1118
Ensembl	ENSG00000133063
String	9606.ENSP00000356198
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Chitinase 1 (CHIT1)

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