Dopamine Receptor D4 (DRD4) Antibody

This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats.

Target	Dopamine Receptor D4 (DRD4)
Clonality	Monoclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB
Host	Mouse
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 365-391 amino acids from the Central region of human DRD4.
Isotype	IgG1
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P21917 (UniProt, ExPASy)
UniProt Secondary AC	B0M0J7, Q7Z7Q5, Q8NGM5
UniProt Entry Name	DRD4_HUMAN
KEGG	hsa:1815
Molecular Weight	Calculated MW: 43.9 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Dopamine Receptor D4 (DRD4)

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