EIF4EBP1 (pT36) Antibody

EIF4EBP1 is a member of a family of translation repressor proteins. This protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. It is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.

Target	EIF4EBP1 (pT36)
Clonality	Polyclonal
Target Modification	Thr36
Modification	Phosphorylation
Reactivity	Human
Tested Applications	ELISA, DB
Host	Rabbit
Recommended dilutions	DB: 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T36 of human EIF4EBP1.
Isotype	IgG
Form	Liquid
Purification	Purified by protein A affinity chromatography. Then, the antibody fraction was peptide affinity purified in a 2-step procedure with peptides. The antibody was eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q13541 (UniProt, ExPASy)
UniProt Secondary AC	B2R502, D3DSW8, Q6IBN3
UniProt Entry Name	4EBP1_HUMAN
KEGG	hsa:1978
String	9606.ENSP00000340691
Molecular Weight	Calculated MW: 12.6 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Rat and Cow EIF4EBP1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on EIF4EBP1 (pT36)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue