Endosulfine Alpha (ENSA) Antibody

ENSA belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes.

Target	Endosulfine Alpha (ENSA)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 39-66 amino acids from the Central region of human ENSA.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O43768 (UniProt, ExPASy)
UniProt Entry Name	ENSA_HUMAN
Gene Symbol	ENSA
KEGG	hsa:2029
Molecular Weight	Calculated MW: 13.4 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Rat, Cow, Pig, Chicken, Zebrafish and Xenopus ENSA.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Endosulfine Alpha (ENSA)

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