Endoplasmic Reticulum To Nucleus Signaling 2 (ERN2) Antibody

ERN2 induces translational repression through 28S ribosomal RNA cleavage in response to endoplasmic reticulum (ER) stress. This pro-apoptotic appears to play no role in the unfolded-protein response, unlike closely related proteins. Overexpression of ERN2 activates both BiP and CHOP expression, and also leads to the development of programmed cell death. It has been suggested that Ern2 plays a role in multiple facets of the ER stress response in mammalian cells.

Target	Endoplasmic Reticulum To Nucleus Signaling 2 (ERN2)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 39-72 amino acids from the N-terminal region of human ERN2.
Isotype	IgG
Form	Liquid
Purification	Purified Rabbit Polyclonal Antibody.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q76MJ5 (UniProt, ExPASy)
UniProt Secondary AC	Q6ZNC0
UniProt Entry Name	ERN2_HUMAN
GeneID	10595
KEGG	hsa:10595
String	9606.ENSP00000256797
Molecular Weight	Calculated MW: 102 kDa
Buffer	PBS containing 0.09% sodium azide.
Concentration	2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Endoplasmic Reticulum To Nucleus Signaling 2 (ERN2)

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