F-Box Protein 8 (FBXO8) Antibody

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a C-terminal amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor (s) (ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity.

Target	F-Box Protein 8 (FBXO8)
Clonality	Polyclonal
Reactivity	Mouse
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 168-195 amino acids from the Central region of human FBXO8.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9NRD0 (UniProt, ExPASy)
UniProt Secondary AC	B2RB40, D3DP41, G5E9Z0, Q6UWN4, Q8IWE1, Q9NRP5, Q9UKC4
UniProt Entry Name	FBX8_HUMAN
Gene Symbol	FBXO8
String	9606.ENSP00000377280
Molecular Weight	Calculated MW: 37.1 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Cow FBXO8.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on F-Box Protein 8 (FBXO8)

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