RNA-Binding Protein FUS (FUS) Antibody

FUS Antibody is a Rabbit Polyclonal antibody against FUS. This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6.

Target	RNA-Binding Protein FUS (FUS)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IF/ICC, IP
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/100, IP: 0.5-4 µg/200-400 µg whole cell extracts. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 297-526 of human FUS.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P35637 (UniProt, ExPASy)
UniProt Secondary AC	Q9H4A8
UniProt Entry Name	FUS_HUMAN
Gene Symbol	FUS
GeneID	2521
NCBI Accession	NP_004951.1
KEGG	hsa:2521
String	9606.ENSP00000254108
Molecular Weight	Calculated MW: 53 kDa Observed MW: 70 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on RNA-Binding Protein FUS (FUS)

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