Glutamate Metabotropic Receptor 4 (GRM4) Antibody

GRM4 Antibody is a Rabbit Polyclonal antibody against GRM4. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene.

Target	Glutamate Metabotropic Receptor 4 (GRM4)
Clonality	Polyclonal
Reactivity	Mouse, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 33-290 of human GRM4.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q14833 (UniProt, ExPASy)
UniProt Secondary AC	B3KVL9, B7Z1T9, B7Z1U6, F5GXM5, Q5SZ84, Q6ZMQ2
UniProt Entry Name	GRM4_HUMAN
Gene Symbol	GRM4
GeneID	2914
NCBI Accession	NP_000832.1
KEGG	hsa:2914
String	9606.ENSP00000440556
Molecular Weight	Calculated MW: 102 kDa Observed MW: 115 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	4.08 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Glutamate Metabotropic Receptor 4 (GRM4)

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