Histone H2B Type F-S (H2BC12L) Antibody

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.

Target	Histone H2B Type F-S (H2BC12L)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 58-84 amino acids from the Central region of human H2BFS.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P57053 (UniProt, ExPASy)
UniProt Secondary AC	A0AVF9, Q5R2W0
UniProt Entry Name	H2BFS_HUMAN
Gene Symbol	H2BFS
GeneID	102724334
KEGG	hsa:102724334
String	9606.ENSP00000481622
Molecular Weight	Calculated MW: 13.9 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Histone H2B Type F-S (H2BC12L)

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