Syncytin-1 (HERV) Antibody

Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. The protein, also known as syncytin, is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. This protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer.

Target	Syncytin-1 (HERV)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 400-429 amino acids from the Central region of human HERV (ERVWE1).
Isotype	IgG
Form	Liquid
Purification	Purified by Saturated Ammonium Sulfate (SAS) precipitation, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9UQF0 (UniProt, ExPASy)
UniProt Secondary AC	B2RPD4, O95244, O95245, Q8NHY7, Q9NRZ2, Q9NZG3
UniProt Entry Name	SYCY1_HUMAN
GeneID	30816
NCBI Accession	NP_001124397.1 NP_055405.3
String	9606.ENSP00000419945
Molecular Weight	Calculated MW: 59.9 kDa
Buffer	PBS containing 0.09% sodium azide.
Concentration	1.5 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Syncytin-1 (HERV)

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